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First published online May 14, 2008
Experimental Biology and Medicine 233:930-940 (2008)
doi: 10.3181/0709-MR-234
© 2008 by the Society for Experimental Biology and Medicine
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MINIREVIEW

Imaging Stem Cell Implant for Cellular-Based Therapies

Zhenghong Lee*,1, James E. Dennis{dagger} and Stanton L. Gerson{ddagger}

* Departments of Radiology and Biomedical Engineering, National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio 44106; {dagger} Department of Orthopedics, National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio 44106; {ddagger} Division of Hematology-Oncology, National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio 44106

To whom requests for reprints should be addressed at 1 Departments of Radiology and Biomedical Engineering, National Center for Regenerative Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106. E-mail: Zxl11{at}case.edu

Stem cell–based cellular therapy represents a promising outlook for regenerative medicine. Imaging techniques provide a means for noninvasive, repeated, and quantitative tracking of stem cell implant or transplant. From initial deposition to the survival, migration and differentiation of the transplant/implanted stem cells, imaging allows monitoring of the infused cells in the same live object over time. The current review briefly summarizes and compares existing imaging methods for cell labeling and imaging in animal models. Several studies performed by our group using different imaging techniques are described, with further discussion on the issues with these current imaging approaches and potential directions for future development in stem cell imaging.

Key Words: stem cell imaging • hematopoietic stem cell • mesenchymal stem cell • bioluminescent imaging • positron emission tomography • cell-based therapy






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